pupG [2017-8-11 16:0:3]

purine nucleoside phosphorylase

Locus: BSU23490

Isoelectric point: 4.86

Molecular weight: 28.98 kDa

Protein length: 271 aa

Gene length: 813 bp

Function: purine salvage and interconversion

Product: purine nucleoside phosphorylase

Essential: no

E.C.: 2.4.2.1

Synonyms: punA, pnp, yqkO

Genomic Context

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Categories containing this gene/protein

• Metabolism → Nucleotide metabolism → Biosynthesis/ acquisition of nucleotides → Purine salvage and interconversion
• Groups of genes → Phosphoproteins → Phosphorylation on a Ser residue

Gene

Coordinates: 2,446,418 → 2,447,233

The protein

Catalyzed reaction/ biological activity

• Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate (according to Swiss-Prot) RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate (according to Swiss-Prot)

Protein family

• PNP/MTAP phosphorylase family (according to Swiss-Prot) polyribonucleotide nucleotidyltransferase family (according to Swiss-Prot)

Modification

• phosphorylation on Ser-28 PubMed

Localization

• secreted (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: drm-pupG
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • CcpA: repression, PubMed, in CcpA regulon

  Regulation

  • induced in the presence of nucleosides (deoxyribose 5-phosphate and ribose 5-phosphate act as molecular inducers) PubMed

References

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